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DNA Damage And Premature Aging - A Molecular Link

General - April 23, 2015 - 6:30pm

Human DNA accumulates damage over time and older bodies can't repair it as well as younger, leading to the obvious conclusion that damage builds up over time and leads to an irreversible dormant state known as senescence.

Cellular senescence is believed to be responsible for some of the telltale signs of aging, such as weakened bones, less resilient skin and slow-downs in organ function. DNA damage also seems to play a role in conditions called progerias, which cause premature aging. Progeria patients have mutations in genes responsible for DNA damage repair. Now researchers from the University of Pennsylvania have pinpointed a molecular link between DNA damage, cellular senescence and premature aging. 


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No Three-Parent IVF Needed: Genome Editing In Mitochondria Prevents Disease Inheritance

Science2.0 - April 23, 2015 - 6:02pm

A proof-of-concept study in mice showed it is possible to prevent transmission of mitochondrial disease to children without resorting to controversial cytoplasmic transfer - "three-parent" IVF.

Mitochondria are known as the powerhouse of the cell because they generate most of the cell's supply of energy. Each cell in the body contains anywhere from 1,000 to 100,000 copies of mitochondrial DNA, which is exclusively transmitted through maternal inheritance. In most patients with mitochondrial disease, mutated and normal mitochondrial DNA molecules are mixed together in cells.


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Categories: Science2.0

No Three-Parent IVF Needed: Genome Editing In Mitochondria Prevents Disease Inheritance

General - April 23, 2015 - 6:02pm

A proof-of-concept study in mice showed it is possible to prevent transmission of mitochondrial disease to children without resorting to controversial cytoplasmic transfer - "three-parent" IVF.

Mitochondria are known as the powerhouse of the cell because they generate most of the cell's supply of energy. Each cell in the body contains anywhere from 1,000 to 100,000 copies of mitochondrial DNA, which is exclusively transmitted through maternal inheritance. In most patients with mitochondrial disease, mutated and normal mitochondrial DNA molecules are mixed together in cells.


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Categories: News

Mosquito Bites Have A Genetic Component, Finds Twins Study

Science2.0 - April 23, 2015 - 4:00pm

The likelihood of being bitten by mosquitoes could be linked to our genes, according to a recent study. Previous papers have suggested that human attractiveness to insects is based on differences in body odor or diet but there has been no clear and consistent dietary explanation. 


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Mosquito Bites Have A Genetic Component, Finds Twins Study

General - April 23, 2015 - 4:00pm

The likelihood of being bitten by mosquitoes could be linked to our genes, according to a recent study. Previous papers have suggested that human attractiveness to insects is based on differences in body odor or diet but there has been no clear and consistent dietary explanation. 


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Antibiotic Shortages Plus Antibiotic Resistance Raise Concerns About Patient Care

Science2.0 - April 23, 2015 - 2:28pm

Increasingly, the public distrusts science and medicine. Much of the reason has been due to lawsuits, some of it has been due to strange beliefs among wealthy elites in well-defined parts of the United States. Due to popularized concerns about the safety of medicine, the approval cycle and the cost is longer than ever - billions of dollars and a dozen or more years unless a disease like Ebola gets into corporate media headlines.


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Categories: Science2.0

Antibiotic Shortages Plus Antibiotic Resistance Raise Concerns About Patient Care

General - April 23, 2015 - 2:28pm

Increasingly, the public distrusts science and medicine. Much of the reason has been due to lawsuits, some of it has been due to strange beliefs among wealthy elites in well-defined parts of the United States. Due to popularized concerns about the safety of medicine, the approval cycle and the cost is longer than ever - billions of dollars and a dozen or more years unless a disease like Ebola gets into corporate media headlines.


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Categories: News

Sensation Of Invisibility Created In The Lab

Science2.0 - April 23, 2015 - 2:21pm

We've long been fascinated by but it has been fictional. Now a team of researchers has created a perceptual illusion of having an invisible body. You won't just 'feel' invisible like no one notices you in a crowd, you can actually feel invisible.

The history of literature features many well-known narrations of invisibility and its effect on the human mind, such as the myth of Gyges' ring in Plato's dialogue The Republic and the science fiction novel The Invisible Man by H.G. Wells.

Recent advances in materials science have shown that invisibility cloaking real world objects might soon be possible in the visible light spectrum. How might invisibility affect our brain and body perception?


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Categories: Science2.0

Sensation Of Invisibility Created In The Lab

General - April 23, 2015 - 2:21pm

We've long been fascinated by but it has been fictional. Now a team of researchers has created a perceptual illusion of having an invisible body. You won't just 'feel' invisible like no one notices you in a crowd, you can actually feel invisible.

The history of literature features many well-known narrations of invisibility and its effect on the human mind, such as the myth of Gyges' ring in Plato's dialogue The Republic and the science fiction novel The Invisible Man by H.G. Wells.

Recent advances in materials science have shown that invisibility cloaking real world objects might soon be possible in the visible light spectrum. How might invisibility affect our brain and body perception?


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Categories: News

High Mountains May Be Warming Faster

Science2.0 - April 23, 2015 - 2:08pm

Higher elevations around the world may be warming much faster than previously thought, according to a paper which reviewed elevation-dependent warming mechanisms such as loss of snow and ice, increased latent heat release at high altitudes, low-elevation aerosol pollutants that increase the difference in warming rates between low and high elevations, plus other factors that enhance warming with elevation in different regions, and in different seasons. 


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Categories: Science2.0

High Mountains May Be Warming Faster

General - April 23, 2015 - 2:08pm

Higher elevations around the world may be warming much faster than previously thought, according to a paper which reviewed elevation-dependent warming mechanisms such as loss of snow and ice, increased latent heat release at high altitudes, low-elevation aerosol pollutants that increase the difference in warming rates between low and high elevations, plus other factors that enhance warming with elevation in different regions, and in different seasons. 


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Experimental Drug Could Aid Frontline Spinal Injury Treatment

Science2.0 - April 23, 2015 - 2:00pm

Rapid treatment with a new anti-inflammatory called
C5aR
could have a major impact on recovery from spinal cord injury.

University of Queensland School of Biomedical Sciences researchers Dr. Marc Ruitenberg and Ph.D. student Faith Brennan said they made the discovery during laboratory trials with an experimental drug. Brennan said that excessive inflammation caused additional damage in spinal cord injuries and hindered recovery. 


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Categories: Science2.0

Experimental Drug Could Aid Frontline Spinal Injury Treatment

General - April 23, 2015 - 2:00pm

Rapid treatment with a new anti-inflammatory called
C5aR
could have a major impact on recovery from spinal cord injury.

University of Queensland School of Biomedical Sciences researchers Dr. Marc Ruitenberg and Ph.D. student Faith Brennan said they made the discovery during laboratory trials with an experimental drug. Brennan said that excessive inflammation caused additional damage in spinal cord injuries and hindered recovery. 


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It's Hubble's 25th Birthday But We Get A Present

Science2.0 - April 23, 2015 - 1:45pm
The Hubble Space Telescope is almost old enough to buy its own health insurance! 

Tomorrow, April 24th, the Hubble Space Telescope will turn 25. For much of that time, it has been a few hundred miles away, providing a peek into the cosmos. It has long exceeded its mission life (good thing too, it's successor will be a decade past its original completion date and 900% over budget, if it even goes up on the latest 2018 date) but that is okay, Hubble shows no signs of letting up.
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Categories: Science2.0

It's Hubble's 25th Birthday But We Get A Present

General - April 23, 2015 - 1:45pm
The Hubble Space Telescope is almost old enough to buy its own health insurance! 

Tomorrow, April 24th, the Hubble Space Telescope will turn 25. For much of that time, it has been a few hundred miles away, providing a peek into the cosmos. It has long exceeded its mission life (good thing too, it's successor will be a decade past its original completion date and 900% over budget, if it even goes up on the latest 2018 date) but that is okay, Hubble shows no signs of letting up.
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Science 2.0: Quantum Theory Makes Big Data Manageable

Science2.0 - April 23, 2015 - 1:35pm

One cornerstone of the Science 2.0 approach is the framework for making Big Data manageable. In fields from physics to biology, it's no longer a question of obtaining data, but managing it in ways that are relevant.

It's been problematic in science just as it has been in business and the public sector because relationships between the different parts of a network have been represented as simple links, regardless of how many ways they can actually interact, and that results in a loss of valuable information in science.


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Categories: Science2.0

Science 2.0: Quantum Theory Makes Big Data Manageable

General - April 23, 2015 - 1:35pm

One cornerstone of the Science 2.0 approach is the framework for making Big Data manageable. In fields from physics to biology, it's no longer a question of obtaining data, but managing it in ways that are relevant.

It's been problematic in science just as it has been in business and the public sector because relationships between the different parts of a network have been represented as simple links, regardless of how many ways they can actually interact, and that results in a loss of valuable information in science.


read more

Categories: News

Baseball Social Media Techniques Increase Fan Engagement

Science2.0 - April 23, 2015 - 1:30pm

Businesses have been expanding their marketing and communication efforts to engage people with their brands through sites such as Facebook and Twitter and they discovered that being open, rather than just engaging in push marketing, helps.


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Categories: Science2.0

Baseball Social Media Techniques Increase Fan Engagement

General - April 23, 2015 - 1:30pm

Businesses have been expanding their marketing and communication efforts to engage people with their brands through sites such as Facebook and Twitter and they discovered that being open, rather than just engaging in push marketing, helps.


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Categories: News

Chilli Peppers May Prevent Liver Damage And Progression

General - April 23, 2015 - 1:24pm

Daily consumption of capsaicin, the active compound of chilli peppers, was found to have beneficial effects on liver damage. The study found capsaicin reduced the activation of hepatic stellate cells (HSCs) in mice models. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.

The mice were split into two groups and received capsaicin in their food:

After three days of bile duct ligation (BDL) in which the common bile duct is obstructed, leading to bile accumulation and liver fibrosis


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