In a world first, Australian researchers have identified a new DNA structure -- called the i-motif -- inside cells. A twisted 'knot' of DNA, the i-motif has never before been directly seen inside living cells. The new findings, from the Garvan Institute of Medical Research, are published today in the leading journal Nature Chemistry.
Early-life obesity and depression may be driven by shared abnormalities in brain regions that process rewards, according to researchers at the Stanford University School of Medicine.
In a new study, published in the Journal of the American Geriatrics Society, researchers identified six tools that caregivers could use to detect delirium in the older adults they provide care for.
In the appropriate clinical setting, suspicion for acute aortic dissection should be raised when patients present with findings that have a high specificity and high positive likelihood ratio (hypotension, pulse deficit, or neurologic deficit).
Today's peace symbols go back to antiquity -- According to archaeologists, peace images were widespread, especially during wars, despite glorification of war -- Oldest peace treaty attests to long negotiations instead of triumphant victory -- Bronze-colored statue of Eirene shown for the first time -- International Peace Conference of the Cluster of Excellence "Religion and Politics" in May presents new research - Exhibition "Peace. From Antiquity to the Present Day" at five locations in Münster
The research team used model spinal cord injuries in rats for their purposes. As a result, it was found out that therapy by adipose-derived mesenchymal stem cells combined with fibrin matrix influences the restoration of motor functions. It also decreases the area of pathological cavities and reduces astroglial activation.
Unlike most hermit crabs, the blanket-hermit crab does not use empty shells for protection, and instead lives symbiotically with a sea anemone. The crab uses the anemone to cover its soft abdomen, and can pull the anemone's tissue over its head to protect itself whenever necessary. Since 1888, this crab had been considered a unique species until a research team recently described five new ones and a new genus in the open access journal ZooKeys.
Extracellular vesicles (EV) represent a promising vector system for biomolecules and drug delivery due to their natural origin and participation in intercellular communication. As the quantity of EVs is limited, it was proposed to induce the release of membrane vesicles from the surface of human cells by treatment with cytochalasin B. Cytochalasin B-induced membrane vesicles (CIMVs) were successfully tested as a vector for delivery of dye, nanoparticles, and a chemotherapeutic.
There are considerable socioeconomic disparities in asthma control among children, but the molecular origins of these disparities are not well understood.
Palbociclib is a drug used for the treatment of advanced estrogen-receptor-positive breast cancer. Researchers at the Universities of Dundee and Newcastle and their colleagues investigated the drug's mode of action in more detail and uncovered the proteasome, a cellular degradation machinery vital for the control of cell proliferation, as its yet unknown target. Their discovery could potentially help expand palbociclib-based breast cancer treatments and identify patients that would profit most from this medication.
An international group of physicists managed for the first time to experimentally observe the transition between two different states of matter: propagating polariton-solitons and a Bose-Einstein condensate. Furthermore, physicists developed a theoretical model to explain such transitions and found a way to switch between the different states by changing the laser pumping power in the polariton formation process. The results are published in Physical Review Letters.
Ever since the first penalty kicks were introduced to soccer in 1891, experts, coaches and supporters have puzzled over the question of why some goalkeepers are better at stopping penalties than others. A new review of the available literature now proves that simply learning which corner to dive to is not enough. It is important that goalkeepers also perfectly calculate their dive to get to the corner at the right time.
A new greener, stronger and more durable concrete that is made using the wonder-material graphene could revolutionise the construction industry.
ECDC data show that up to 80 percent of teenagers and young adults who contracted measles in 2017 had not been vaccinated. ECDC analysis of sub-national data indicates that even countries with high overall levels of vaccine coverage may have groups that are unvaccinated. In recent and ongoing measles outbreaks, ECDC's recent rapid risk assessment identifies healthcare workers as among those affected.
Little is known concerning how extensively drugs are prescribed to newborns in different neonatal intensive care units (NICUs).
A new high-power laser system generates ultrashort pulses of light covering a large share of the mid-infrared spectrum.
An international team of scientists including the University of Adelaide has discovered a new complex carbohydrate in moss that could possibly be exploited for health or other uses.
A high-sensitive blood test can aid concussed hockey players when it might be safe to return to play. In a study published by the journal Neurology, researchers at Sahlgrenska Academy has identified a superior blood-based biomarker for assessing subtle brain injury.
A team of Russian scientists together with foreign colleagues found out that the venom of crab spider Heriaeus melloteei may be used as a basis for developing treatment against hypokalemic periodic paralysis.
A team of scientists from the Faculty of Chemistry and the Faculty of Materials Science, MSU together with foreign colleagues discovered that two-dimensional sheets of cadmium telluride can spontaneously fold into nanoscrolls. This effect may be used in electronics and photonics. The results of the study were published in the highly-rated Chemistry of Materials journal.