Different tissues have shockingly variable sensitivities to genes that drive normal and malignant cell proliferation, study shows.Research unmasks hundreds of cancer-driving genes invisible to gene sequencing.Findings could explain why individual cancer drivers appear in some tumors and not others, could inspire tissue-specific strategies for cancer treatment.
Putting mice on a diet containing low amounts of the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, according to a new study from Harvard T.H. Chan School of Public Health. The finding adds insight to previous research showing that a methionine-restricted diet extends lifespan and healthspan, suggesting that improved vascular function may contribute to these benefits.
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Kelsea Marie Hubka, a Rice University graduate student and visiting student at University of Texas Health Science Center School of Dentistry, Houston, Texas, presented a poster titled 'Growth Factor Gradients in Migration-Permissive Hydrogels for Salivary Gland Assembly.'
MIT researchers have reversed age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth. Their study, led by senior author Leonard Guarente, found the compound, which reactivates longevity-linked sirutin proteins, promotes blood vessel and muscle growth, boosting endurance of elderly mice by up to 80 percent.
In work that brings researchers closer to the goal of precision medicine approaches to treating glaucoma and other neurodegenerative vision diseases, a new IUPUI study has, for the first time, been able to identify a wide variety of previously unknown cell subtypes in the human eye.
Discovery of why two of the most economically important bee species are immune to one neonicotinoid insecticide but not to others promises to yield chemical treatments that protect crops from pests without harming these essential pollinators, honeybees and bumblebees.Bee pollinators are equipped with biochemical defence systems, in the form of specific enzymes, that define their sensitivity to insecticides by enabling them to metabolise the chemicals safely, report an international team of researchers.
Efforts to create pesticides that are not toxic to bees have been boosted by a scientific breakthrough.
Biological rhythms are ubiquitous in nature, from the beating of the heart to the rhythms of flowering plants. A research team led by the Spanish researcher, Paloma Mas, has shown that the two main cellular oscillators -- the circadian clock and the cell cycle -- are closely connected. The study demonstrates that the circadian clock controls the speed of the cell cycle, regulating the cell division and growth in synchronization with the day and night cycles.
Researchers have discovered a novel mechanism through which information can be effectively transmitted across many areas in the brain -- a finding that offers a potentially new way of understanding how consciousness arises.
Scientists identify mechanism behind vascular aging, muscle demise in mice. Treatment with chemical compounds reversed vascular aging, stimulated blood vessel growth and blood flow, boosted exercise capacity in aging animals.
An enzyme called SIRT1 declines in the blood vessels with age and restoring it reverses the effects of vascular aging. After receiving a supplement called NMN, older mice showed increased capillary density, blood flow, mobility, and endurance.
One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15 percent for two years slowed aging and metabolism and protected against age-related disease. The study, which will appear March 22 in the journal Cell Metabolism, found that calorie restriction decreased systemic oxidative stress, which has been tied to age-related neurological conditions such as Alzheimer's and Parkinson's diseases, as well as cancer, diabetes, and others.
A team of biologists has deciphered how neurons used in the perception of motion form in the brain of a fly -- a finding that illustrates how complex neuronal circuits are constructed from simple developmental rules.
Different behaviors are often studied in isolation, leaving unanswered questions about how the brain processes needs and prioritizes behaviors to ensure survival. Now, researchers have shown that pain and hunger interact in complex ways in mice: extreme hunger suppresses less-urgent inflammatory pain, but leaves them able to feel and react to more life-and-death kinds of pain. The study, published March 22 in Cell, pinpoints a highly specific neural circuit that creates this analgesic effect.
You've probably heard that the safety of neonicotinoid pesticides to bees is a matter of considerable controversy. However, neonicotinoids show varying toxicity to bees. Now, researchers reporting in the journal Current Biology on March 22 have new evidence in honeybees and bumble bees that helps to explain why bees differ in their sensitivity to different neonicotinoids.
Animals that carry a physical impediment can work harder to rear their young as a result, an insect study has shown. They may behave this way in case they are not able to reproduce again, scientists suggest.
A University of Chicago based research team has begun to unravel the role of RNA epigenetics and chromatin structure in the regulation of 5-azacytidine, a DNA hypomethylating agent in certain leukemias. The results could lead to novel strategies and biomarkers that could reduce the risk of drug resistance.
Stellar grades in college could hurt -- rather than help -- women new to the job market, according to a new study that suggests employers place more value on the perceived 'likability' of female applicants than on their academic success.
Researchers have identified a receptor on plant stem cells that can issue different instructions about how to grow. Tweaking this pathway can lead to bigger fruits or more seeds in important food crops.
Medical school students receive little formal instruction in radiation oncology, a Loyola study has found. Researchers who surveyed radiation oncology departments at academic medical centers found that only 41 percent of departments reported that at least one faculty member taught a topic related to radiation oncology. In only 25 percent of departments, a faculty member taught topics focused specifically on radiation oncology.