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New 'atlas' charts how antibodies attack spike protein variants

Eurekalert - Jul 23 2021 - 00:07
Now, researchers from Brigham and Women's Hospital and collaborators have created an "atlas" that charts how 152 different antibodies attack a major piece of the SARS-CoV-2 machinary, the spike protein, as it has evolved since 2020. Their study, published in Cell, highlights antibodies that are able to neutralize the newer strains, while identifying regions of the spike protein that have become more resistant to attack.
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Reverse optogenetic tool developed

Eurekalert - Jul 23 2021 - 00:07
A new optogenetic tool, a protein that can be controlled by light, has been characterized by researchers at Ruhr-Universität Bochum. They used an opsin - a protein that occurs in the brain and eyes - from zebrafish and introduced it into the brain of mice. Unlike other optogenetic tools, this opsin is not switched on but rather switched off by light. Experiments also showed that the tool could be suitable for investigating changes in the brain that are responsible for the development of epilepsy.
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Bio-based coating for wood outperforms traditional synthetic options

Eurekalert - Jul 23 2021 - 00:07
Researchers at Aalto University have used lignin, a natural polymer abundant in wood and other plant sources, to create a safe, low-cost and high-performing coating for use in construction. As there is a global urge to meet the rising sustainability standards, this new coating has great potential to protect wood, whose use in construction is continually increasing. The new coating is non-toxic, hydrofobic, it retains wood's breathability and natural roughness while being resistant to colour changes and abrasion.
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Phase two CD19-antibody-drug conjugate trial demonstrates promise for aggressive lymphoma

Eurekalert - Jul 23 2021 - 00:07
MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma. The results of the single-arm, phase 2 trial were published online in May 2021 in Lancet Oncology.
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Novel imaging agent identifies biomarker for iron-targeted cancer therapies

Eurekalert - Jul 23 2021 - 00:07
A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration in tumors, which can help predict whether a not the cancer will respond to treatment. This research was published in the July issue of The Journal of Nuclear Medicine.
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China's carbon-monitoring satellite reports global carbon net of six gigatons

Eurekalert - Jul 23 2021 - 00:07
About six gigatons -- roughly 12 times the mass of all living humans -- of carbon appears to be emitted over land every year, according to data from the Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite (TanSat).
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Research 'final nail in the coffin' of Paranthropus as hard object feeders

Eurekalert - Jul 23 2021 - 00:07
New research from the University of Otago debunks a long-held belief about our ancestors' eating habits.
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Researchers uncover fatal flaw in green pigmented concrete

Eurekalert - Jul 23 2021 - 00:07
Researchers from Xi'an Jiaotong-Liverpool University have found that an impurity present in many industrial pigmentations drastically reduces the strength and longevity of green architectural concrete.
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How the brain paints the beauty of a landscape

Eurekalert - Jul 23 2021 - 00:07
Researchers investigate how our brains proceed from merely seeing a landscape to feeling its aesthetic impact
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New insights into immune responses to malaria

Eurekalert - Jul 23 2021 - 00:07
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.
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Mount Sinai researchers develop novel therapy that could be effective in many cancers

Eurekalert - Jul 23 2021 - 00:07
Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July.
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Bacteria navigate on surfaces using a 'sense of touch'

Eurekalert - Jul 23 2021 - 00:07
EPFL researchers have characterized a mechanism that allows bacteria to direct their movement in response to the mechanical properties of the surfaces the microbes move on -- a finding that could help fight certain pathogens.
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Blushing plants reveal when fungi are growing in their roots

Eurekalert - Jul 23 2021 - 00:07
Scientists have created plants whose cells and tissues 'blush' with beetroot pigments when they are colonised by fungi that help them take up nutrients from the soil. This is the first time this vital, 400 million year old process has been visualised in real time in full root systems of living plants. Understanding the dynamics of plant colonisation by fungi could help to make food production more sustainable in the future.
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Research identifies potential role of 'junk DNA' sequence in aging, cancer

Eurekalert - Jul 23 2021 - 00:07
Researchers at Washington State University have recently identified a DNA region known as VNTR2-1 that appears to drive the activity of the telomerase gene, which has been shown to prevent aging in certain types of cells. Knowing how the telomerase gene is regulated and activated and why it is only active in certain cell types could someday be the key to understanding how humans age and how to stop the spread of cancer.
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Device cracks milk protein

Eurekalert - Jul 23 2021 - 00:07
After gaining world attention by 'unboiling' egg protein, Flinders University scientists have now used an Australian-made novel thin film microfluidic device to manipulate Beta-lactoglobulin (β-lactoglobulin), the major whey protein in cow's, sheep's and other mammals.In the latest application, published in Molecules, College of Science and Engineering experts have combined the capabilities of the VFD with a new form of biosensor called TPE-MI, which is an aggregation-induced emission luminogen (AIEgen).
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Child mental health services lacking in high-income countries: SFU study finds

Eurekalert - Jul 23 2021 - 00:07
Most children with a mental health disorder are not receiving services to address their needs--according to a new study from researchers at Simon Fraser University's Children's Health Policy Centre. Their research was published this week in the journal Evidence-Based Mental Health.
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Scientists identify five new plant species in Bolivia

Eurekalert - Jul 23 2021 - 00:07
Scientists have identified five new plant species in the Bolivian Andes. The species are all part of the genus Jacquemontia, which are twining or trailing plants with pretty blue flowers.
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Water resources: Defusing conflict, promoting cooperation

Eurekalert - Jul 23 2021 - 00:07
The EU funded project DAFNE has developed a methodology for avoiding conflicts of use in transboundary rivers. The model-?based procedure allows for participatory planning and cooperative management of water resources. The aim is now for the DAFNE methodology to be implemented in other regions of the world.
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Chemotherapy can induce mutations that lead to pediatric leukemia relapse

Eurekalert - Jul 23 2021 - 00:07
A collaboration led by St. Jude Children's Research Hospital, Shanghai Children's Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
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Topology in biology

Eurekalert - Jul 23 2021 - 00:07
A phenomenon known from quantum systems could now make its way into biology:In a new study published in Physical Review X, researchers from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) in Goettingen show that the notion of topological protection can also apply to biochemical networks. The model which the scientists developed makes the topological toolbox, typically used only to describe quantum systems, now also available to biology.
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