A cellular adhesion protein protects against inflammation

Posted By News On February 9, 2013 - 9:31pm

Cellular inflammation is mediated by a group of proteins known as the inflammasome.

In the Journal of Clinical Investigation, Ziad Mallat and colleagues at Addenbrooke's Hospital in Cambridge, England, identified a protein, MFGE8, that blocks inflammasome activity.

Using a mouse model of stroke, Mallat and colleagues determined that expression of MFGE8 inhibited the production of pro-inflammatory products and limited the area of injury after stroke.

These results identify MFGE8 as an important regulator of inflammation that could potentially serve as a useful therapeutic target in inflammatory disease.

TITLE:MFGE8 inhibits inflammasome-induced IL-1β production and limits post-ischemic cerebral injury

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