New potential drug target for the treatment of atherosclerosis

New potential drug target for the treatment of atherosclerosis

LA JOLLA, CA — A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone to developing the harmful plaques, according to new research by scientists at the Salk Institute for Biological Studies and the Harvard School of Public Health.

News and features abound at ACS National Meeting in New Orleans, April 6-10

NEW ORLEANS — Blood from the American alligator — the creature feared for attacks on people and pets — may have a new role as a medical lifesaver. Crime scene investigators get a more accurate test for gunshot residue. How research on clay is pointing the way to new rub-on medicines for stubborn antibiotic-resistant skin infections. Welcome to the “Black Gold” agriculture revolution, and its promise for feeding a hungry world.

Sticky blood protein yields clues to autism

Many children with autism have elevated blood levels of serotonin – a chemical with strong links to mood and anxiety. But what relevance this “hyperserotonemia” has for autism has remained a mystery.

New research by Vanderbilt University Medical Center investigators provides a physical basis for this phenomenon, which may have profound implications for the origin of some autism-associated deficits.

Comprehensive diagnosis of heart disease with a single CT scan

CHARLESTON, S.C. (March 4, 2008) – In the current issue of the journal Circulation, a research team from the Medical University of South Carolina’s (MUSC) Heart & Vascular Center report their initial experience with a novel imaging technique that enables comprehensive diagnosis of heart disease based on a single computerized tomographic (CT) scan.

'Renal Assist Device' reduces risk of death from acute kidney failure

For patients with acute kidney injury (AKI), an external device containing human kidney cells promotes recovery of the injured kidneys and significantly reduces the risk of death, according to a preliminary clinical study published in the May Journal of the American Society of Nephrology.

Dana Foundation releases arts and cognition research

Washington, DC, March 4, 2008 – Learning, Arts, and the Brain, a study three years in the making, is the result of research by cognitive neuroscientists from seven leading universities in the United States. In the Dana Consortium study, released today at a news conference at the Dana Foundation’s Washington, DC headquarters, researchers grappled with a fundamental question: Are smart people drawn to the arts or does arts training make people smarter"

Neural progenitor cells as reservoirs for HIV in the brain

Impaired brain function is a prominent and still unsolved problem in AIDS . Shortly after an individual becomes infected with HIV, the virus can invade the brain and persist in this organ for life. Many HIV-infected individuals experience disturbances in memory functions and movement, which can progress to serious dementia. How the virus causes brain disease is still unclear.

Women are treated less frequently than men with statins, aspirin and beta-blockers

CHICAGO – Women and men experience a similar prevalence of adverse drug reactions in the treatment of coronary artery disease; however, women are significantly less likely than their male counterparts to be treated with statins, aspirin, and beta-blockers according to a new study by researchers at Rush University Medical Center. The study is published in the March issue of the journal Gender Medicine.

Protein target for diabetes drug regulates blood pressure

University of Iowa researchers have identified a molecular pathway in blood vessels that controls blood pressure and vascular function and may help explain why certain drugs for type II diabetes also appear to lower patients' blood pressure. The study is published in the March 5 issue of Cell Metabolism.

New insight into blood pressure control may explain diabetes drugs' side benefit

Drugs known as thiazolidinediones (TZDs), which are used to treat type 2 diabetes, seem to come with an added side benefit: They lower blood pressure. Now, researchers reporting in the March issue of Cell Metabolism, a publication of Cell Press, provide new evidence as to why.

The researchers show that so-called peroxisome proliferator-activated receptor Ó (PPARÓ)—a molecule that stands at the crossroads of metabolic and cardiovascular diseases and is the target of TZDs—plays an unanticipated protective role in the blood vessel wall.