Researchers have identified a key mechanism by which the protein sludge that kills brain cells accumulates in Alzheimers disease (AD). Their findings in mice offer clues to treating AD and also could explain why memory centers of the brain are most affected in the disease.
Researchers have identified, for the first time, long-term changes in the brain circuitry of methamphetamine-addicted mice that can explain why the craving of addiction is so stubborn and long-lived. The research could lead to more effective treatments for addiction to methamphetamine and related drugs.
Nigel Bamford and colleagues published their findings in the April 10, 2008, issue of the journal Neuron, published by Cell Press.
STANFORD, Calif. - With a bit of genetic trickery, researchers at the Stanford University School of Medicine have turned normal skin cells into cancer stem cells, a step that will make these naturally rare cells easier to study.
Cancer stem cells are thought to be the ones that drive a cancer, and are therefore the targets of any cancer therapy that must kill them in order to be effective. Understanding these cells has been a challenge, however, because they are rare, difficult to isolate and don't grow well in the lab.
A new study suggests that a genetic fingerprint associated with normal embryonic stem cells may be important for the development and function of cancer stem cells. The research, published by Cell Press in the April 10th issue of Cell Stem Cell, demonstrates that embryonic stem cells and multiple types of human cancer cells share a genetic expression pattern that is repressed in normal differentiated cells, a finding that may have significant clinical implications for cancer therapeutics.
Biological Psychiatry, in its upcoming April 15th issue, is publishing a critical commentary written by its Editors, members of its Editorial Committee, and its Editorial Board.
The commentary is an urgent public statement highlighting the increasing problem of terrorist acts by individuals affiliated with groups such as the Animal Liberation Front against investigators conducting research in non-human primates in the United States.
April 9, 2008 High cholesterol levels are considered to be a risk factor for cardiovascular disease including stroke. Therefore, many cholesterol lowering drugs have been developed by pharmaceutical companies in recent years. One class of these drugs, statins, has been found to reduce the incidence of stroke and progression of Alzheimers disease when prophylactically administered.
Reston, Va.—The extraordinary action of a new cellular therapy came to light as a result of powerful PET and SPECT imaging in a recent study reported in the April issue of the Journal of Nuclear Medicine. Researchers in Germany were able to observe the repair action of circulating progenitor cells (CPCs), immature blood-derived cells capable of developing into adult stem cells, as they successfully preserved healthy heart tissue and corrected blood flow imbalance within the heart.
PROVIDENCE, R.I. A new study by researchers at Hasbro Childrens Hospital offers a closer look at the association between childhood sleep-disordered breathing (SDB), including snoring and sleep apnea, and behavioral problems like hyperactivity and anxiety.
Published in the April issue of the Archives of Pediatric and Adolescent Medicine, the study revealed that children with SDB who are also overweight, sleep for short periods of time, or have another sleep disorder like insomnia are more likely to have behavior issues.
BOSTON, MA, April 9, 2008 New devices and research for mechanical circulatory support in pediatrics from the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Pediatric Circulatory Support Program will be discussed at the International Society for Heart and Lung Transplantation (ISHLT) 28th Annual Meeting and Scientific Sessions. The meeting is ongoing this week at the Boston Marriott Copley Place and Hynes Convention Center.
COLUMBUS, Ohio An oil made of natural fatty acids that is sometimes used as a weight-loss supplement may need to be paired with hormones or other substances to prevent health problems that can follow rapid weight loss, a new study suggests.
Conjugated linoleic acid (CLA), a compound naturally found in some meat and dairy products, can reduce body fat in some studies in humans. But a recent study in mice found that the hormone leptin adds an element of protection against side effects that can accompany fat loss with CLA.