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454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
The study demonstrates the efficacy of this new method by employing 454 Sequencing to sequence the entire mitochondria from 10 individual woolly mammoths. Several of the hair samples investigated were up to 50,000 years old with one sample being stored in a Russian museum for 200 years at room temperature. To put this new study in perspective, only seven mitochondrial genomes from extinct animals had been previously published.
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